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4 ROS in disease pathophysiology Because of cellular metabolism, eukaryotic cells continuously generate endogenous ROS

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Nanocarrierbased delivery systems (e.g., liposomes, polymeric nanoparticles, solid lipid nanoparticles) improve the solubility, bioavailability, and tumortargeting of phytochemicals, thereby enhancing their therapeutic index as adjuncts to conventional therapy (cited [184, 185, 186])

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ActRII inhibitors such as bimagrumab have the strongest body-composition data, but consistent functional benefits and long-term safety in diverse populations are lacking

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