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In human dental pulp stem cells (hDPSC), the expression of the osteogenic markers RUNX2 , COL1 , osteonectin, and osteocalcin was upregulated via the LINC00968/miR-3658 axis [27]
In one representative experiment, rats treated with indomethacin to induce severe gastric lesions showed near-complete mucosal restoration within five days of BPC-157 administration, compared to ongoing lesion progression in untreated controls
The extent of weight loss likely also reflects the potency of anti-inflammatory effect, and biomarkers indicative of reduced inflammation have been shown to precede wight loss in multiple trials of this drug class
In this, pentadecapeptide BPC 157 consistently (grossly, microscopically, and biomechanically) cured burn injuries, and counteracted corticosteroid (6-methylprednisolone 1.0 or 10 mg/kg/day ip for 21 days)-induced impairment of burn healing (Mikus et al., 2001
