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[21] You should arrange to speak with your GP about cholesterol screening if: You have a family history of premature cardiovascular disease (heart attack or stroke in a first-degree relative before age 60) or familial hypercholesterolaemia You have been diagnosed with type 2 diabetes, high blood pressure, or chronic kidney disease You are significantly overweight or obese (BMI 30 kg/m) You smoke or have recently quit smoking You have other cardiovascular risk factors such as a sedentary lifestyle or unhealthy diet You have a QRISK3 score of 10% or higher (if previously calculated) You have signs that might suggest familial hypercholesterolaemia, such as tendon xanthomata (fatty deposits around tendons) or very high LDL cholesterol levels If you are already taking cholesterol-lowering medication , you should contact your GP if you experience: Unexplained muscle pain, tenderness, or weakness (potential sign of statin-related myopathy) Severe muscle pain with dark urine (seek urgent medical attention as this could indicate rhabdomyolysis) Persistent gastrointestinal symptoms affecting your quality of life Concerns about medication side effects or interactions Difficulty adhering to your prescribed treatment regimen For patients with type 2 diabetes currently taking Ozempic who are concerned about their cholesterol levels, it is important to have an open conversation with your GP or diabetes specialist nurse

Read the full paper here: #AlmacSciences #ProcessChemistry #Pharma To view or add a comment, sign in 89,950 followers In drug discovery, activity cliffs reveal the exact structural levers that control target potency, selectivity, and ADMET properties

Motilin agonists have been explored as a treatment for gastroparesis, but no current compounds are available for investigational use [53]

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This uncertainty could lead an individual to prefer a more well-established, longer-standing treatment or a non-pharmaceutical approach to weight loss