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These medications are widely viewed as a win for people struggling with weight loss
A pre-bed dose is timed to reinforce that natural nocturnal pulse, which is why the pre-bed slot is the one most consistently kept even in a once-daily schedule
doi: 10.1056/NEJMoa2307563 13 American Diabetes Association Professional Practice Committee
In the SURPASS and SURMOUNT trials, nausea was reported in up to 32% of participants, diarrhea in 23%, vomiting in 12%, and constipation in 11%
The TRIUMPH-4 results at 68 weeks (28.7% weight loss at 12mg) are the most mature Phase 3 data available
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