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FDA scientific reviewers had advised against adding any of the peptides, citing a lack of robust clinical evidence and unanswered safety questions, but supporters argued that regulated compounding would provide a safer alternative to the growing grey market, where the substances are widely sold as research-grade products despite not being approved for human use

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Advanced Recomp Stack Clinical Evidence Context Critical note No published trial has evaluated retatrutide + CJC-1295 (No DAC) + ipamorelin together

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