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or fasting glucose 5.6 mmol/L [17]

Heart Rate Changes Dose-dependent increases in heart rate peaked at 24 weeks and declined thereafter in clinical trials

Semaglutide should not be used with other GLP-1 receptor agonists or semaglutide-containing products

Regulatory decisions are anticipated in 2026

[16] [87] [88] This includes noradrenergic neurons in the locus coeruleus, dopaminergic neurons in the ventral tegmental area, histaminergic neurons in the tuberomammillary nucleus, and serotonergic neurons in the dorsal raphe nucleus