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Overexpression of IRP2 or MPP + treatment significantly enhances the binding of IRP2 to p53 in PC-12 cells, upregulates p53 levels, downregulates SLC7A11 expression, and increases arachidonate 12-Lipoxygenase (ALOX12) expression, thereby promoting ferroptosis and amino acid antioxidant system disruptions, elevating MDA levels, and inducing PC-12 cell damage

In states of high iodine intake, increased hydrogen peroxide generation enhances oxidative stress within thyroid follicles, promoting antigen presentation and autoimmune activation (151)

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Loading: Increase to 800 mcg daily for Weeks 34

These are not dramatic changes