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National Institute on Aging
10.1016/j.amjsurg.2009.06.008 15 BoyagesJ.XuY.KalfaS.KoelmeyerL.ParkinsonB.MackieH.et al (2017)
The glucose-dependent insulin secretion mechanism of GLP-1R and GIPR agonism means that insulin release is amplified only when blood glucose is elevated, reducing the risk of hypoglycaemia compared to insulin or sulfonylurea-based interventions
Over the subsequent 48 weeks, participants who continued semaglutide experienced an additional mean weight loss of 7.9%, whereas those switched to placebo regained 6.9% of body weight, resulting in a significant 14.8 percentage-point treatment difference
He termed the phenomenon as bluthirnschranke - the blood brain barrier in German [1, 2]
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