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A BMI of 27 is considered overweight but certainly isnt obese, and the reductions in cardiovascular risk seemed somewhat larger in people with a relatively lower BMI
Participants who were smokers (27%) also recorded number of cigarettes smoked per day (GLP-1 drugs are also thought to help reduce smoking and the craving for nicotine)
The overall cardiometabolic benefit of GLP-1RA rapidly expanded beyond the T2DM population, with the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) trial describing MACE reduction in the population with overweight and obesity, even in the absence of T2DM [14]
Gordon describes a newer neuroinflammatory panel containing multiple markers, used before and after treatment to provide objective evidence that inflammatory signaling has changed
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