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M1 macrophages, typically activated by IFN-, are characterized by the production of IL-1, TNF-, IL-6, and iNOS, and are closely associated with synovial inflammation and tissue destruction (106)
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This finding accounts for the important observation that the c-met binding affinity of LASSS/peroxynitrite-treated HGF (at the 1:8000:2000 molar ratio to HGF, with the wash-out of un-reacted free LASSS) was significantly higher than the original level of un-treated positive control HGF (Figure 2d, bars 2 and 6 )
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