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Moreover, AMPK also stimulates autophagy independently of the mTOR signaling pathway through activating phosphorylation of ULK1 (Kim et al., 2011) (Figure 5)
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Further studies will be needed to investigate the physiological relevance of inhibiting or activating NAPRT in non-cancer chronic conditions, such as aging and age-associated diseases
For instance, co-administering CUR with PPR or RSV significantly enhances CURs bioavailability, amplifying its anti-inflammatory (33), apoptotic, and anticancer effects (34, 97)
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