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Trials with older GLP-1 drugs (liraglutide, exenatide) including the large ADJUNCT ONE and ADJUNCT TWO studies showed modest HbA1c improvements of 0.10.7%, meaningful weight loss, and lower insulin requirements, but also raised early concerns about hypoglycemia and ketosis that kept enthusiasm in check for years
They found that those who took GLP-1s had a 46% lower risk of death from any cause during the follow-up period of about 5.5 years
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Amyotroph Lateral Scler Other Mot Neuron Disord 2:918 Graf M, Ecker D, Horowski R et al (2005) High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study