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Liraglutide is a human GLP-1 derivative, which is characterized by the retention of unaltered Ala at position 8, and structural modifications of amino acids at position 26 and 34 (Gong et al., 2024)
Primary APP23 mouse neurons were infected with lentivirus carrying scramble sequence or short-hairpin RNA (shRNA) sequence targeting AMPK, with or without treatment of exendin-4
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Differential diagnoses to consider include pre-existing osteoarthritis exacerbated by increased activity, fibromyalgia, vitamin D deficiency, thyroid dysfunction, or other rheumatological conditions
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