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Lower treatment burden While retatrutide shows significant promise, Eli Lilly is likely to disrupt the market more imminently and more substantially following the launch of orforglipron in early 2026

For patients considering GLP-1 treatment, understanding the clinical evidence, your individual biomarkers, and treatment readiness is essential

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When to Contact Your Healthcare Provider While nausea is common and usually manageable, you should contact your healthcare provider if: Nausea is severe or persistent Youre vomiting frequently Youre unable to keep down fluids (risk of dehydration) Youre considering stopping your medication Symptoms arent improving with the strategies above Severe vomiting or diarrhea can lead to dehydration, which can cause serious complications including acute kidney injury and heart palpitations