[^1^]: source: "Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 19902016: a systematic analysis for the Global Burden of Disease Study 2016", The Lancet [^2^]: source: "Transforming healthcare with AI: The impact on the workforce and organizations", Nature Medicine [^3^]: source: "Artificial intelligence in healthcare: Anticipating challenges and opportunities", BMJ [^4^]: source: "The impact of artificial intelligence - Widespread job losses", The Economist) [^5^]: source: "Artificial Intelligence in Health Care: Anticipating Challenges to Ethics, Privacy, and Bias", Pennsylvania Bioethics Journal [^6^]: source: "Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes", The New England Journal of Medicine [^7^]: source: "Artificial intelligence and diabetes management: a systematic review and meta-analysis", Journal of Diabetes Science and Technology [^8^]: source: "The Role of Prompt Engineering in Healthcare", Journal of Behavioral Medicine [^9^]: source: "AI and Personalized Messaging in Healthcare", Journal of Medical Systems [^10^]: source: "Ethical Considerations in Prompt Engineering", Journal of Medical Ethics [^11^]: source: "AI-Generated Prompts and Medication Adherence", Journal of Diabetes Science and Technology

Standard dosing ranges from 200 to 500mcg per day for most adult protocols
The rationale is that NAD levels decline with age, affecting cellular energy production
Reduced preference
Adverse effects also differ: women report higher rates of gastrointestinal intolerance (nausea, vomiting, cholelithiasis) with incretin-based therapies, likely due to estrogens effects on biliary motility [182]