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Melanocortin-1 receptor (MC1R): pharmacology and therapeutic prospects
(2) A rapid surge in popularity has occurred, with prescription volumes increasing by 300% between 2020 and 2022 alone
Interestingly, a study that did implement this titration approach found during the maintenance phase, rats treated with semaglutide showed a unexpected marked increase in the intake of lower concentrations of sucrose compared to vehicle treated controls, despite continuing to consume chow at only 90% the level of vehicle-treated animals ( In line with clinical data, GLP-1R agonism may also directly influence food preference through modulation of taste receptor expression
Indeed, a phase II dose-finding trial demonstrated greater body weight reductions associated with daily subcutaneous semaglutide at a dose greater than 0.2 mg compared with liraglutide 3.0 mg daily [35]
Y.HyunK.JangS
