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For this reason, it was thought that the enzyme played an important role in ammonia detoxification, because since high [NH 4 + ] are toxic, this equilibrium position would be physiologically important
In turn, lactate-induced H3K18la upregulates SRSF10 expression in macrophages, eventually forming the SRSF10/glycolysis/H3K18la positive feedback loop with tumor cells and promoting M2 macrophage polarization in the tumor microenvironment (TME)
Growth Hormone & IGF Research , 11(5), 266-272
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This mechanism is influenced by the increase of LH hormone [7]
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