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Nutrient-induced gut peptides can act in a paracrine fashion by activating vagal neurons that innervate tissue near the intestinal epithelium and signal to the brain or in an endocrine fashion targeting the brain and other peripheral organs involved in maintaining metabolic homeostasis 17

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A reaction that is larger than usual, lasts longer than usual, or happens more strongly after each dose is worth discussing with your healthcare provider

Medication Adjustment Period Like many medications, semaglutide requires an adjustment phase

Neither one is wrong