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This is the optimal configuration for high-dose maintenance
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OBSCN gene variants have been previously implicated in inherited cardiomyopathies and, more recently, biallelic loss-of-function variants have been implicated in causing exercise intolerance, rhabdomyolysis, and myoglobinuria without any evidence of concomitant cardiomyopathy in nine unrelated patients (116
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Troth SP, Simutis F, Friedman GS, Todd S, Sistare FD (2019) Kidney SAFETY ASSESSMENT: CURRENT PRACTICES IN DRUG DEVELOPMENT
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