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A meta-analysis of 6 studies 13,20,30,32,33,35 which attempted to estimate overall effect size of the changes from baseline in % FMD following GLP-1-based therapies could not find any significant difference between baseline and end-of-treatment samples (mean change from baseline was 0.83 [1.06, 2.73] %
The critical question is whether Phase 3 trials will confirm the Phase 2 efficacy signal and establish an acceptable safety profile for this glucagon-favoring dual agonist
Vagal afferents mediate early satiation and prevent flavour avoidance learning in response to intraperitoneally infused exendin-4
Journal of Clinical and Translational Science , 7 (1), e184
Sodium-glucose co-transporter 2 (SGLT2) inhibitor canagliflozin suppresses TECs apoptosis via maintaining metabolic homeostasis (119), while boeravinone C, an PPAR activator/agonist, can alleviate lipid accumulation and inflammation, thereby suppressing tubular apoptosis (120)
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