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10.1002/ptr.8013 472 WangD.PengY.XieY.ZhouB.SunX.KangR.et al (2016b)
By suppressing tyrosinase activity, it shifts melanin production from eumelanin (dark, brown pigment) toward phaeomelanin (lighter pigment), progressively reducing skin darkness and evening out tone across treatment cycles
This can lead to the accumulation of toxins, which may contribute to fatigue, brain fog, and more serious conditions like liver dysfunction
When activated, Nrf2 disassociates from its repressor protein KEAP1 that reacts with oxidative radicals, translocates to the nucleus, binds to antioxidant response element and induces the transcription of defensive genes
Some people, however, struggle to maintain adequate levels of this vitamin due to various factors such as diet, absorption issues, or certain medical conditions
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