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22, the G/D-CuP group showed a significantly lower proportion of CD86-positive cells compared to the negative control (NC) group
In SELECT, a multicenter trial of patients with overweight or obesity and preexisting cardiovascular disease, semaglutide 2.4 mg reduced weight and the risk of major adverse cardiovascular events while also improving glycated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride levels [16, 17]
That is a clinically meaningful secondary benefit for patients with type 2 diabetes, but it is not the same as the weight loss observed in obesity-specific trials at higher doses
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