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One study found that free phenol and p-cresol chemicals can enter the bloodstream and contribute to skin symptoms
It also isn't all that soluble in water, so only around 20-50% of it is bioavailable to the human body.3 The quantity of silymarin in Life Extension may be lower than that of NOW Foods or HUM Nutrition, but it's integrated with phospholipids
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doi:10.1080/00325481.2019.1643635 Meneilly GS, Ryan EA, Radziuk J, Lau DC, Yale JF, Morais J,
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