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BAC calculation doesnt have a single universal method
For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101
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This approach frequently leads to chronic instability, recurrent injuries, and long-term dysfunction that could have been prevented with appropriate intervention during the initial healing window
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