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Semaglutide is not recommended for those with a personal or family history of certain endocrine or thyroid tumors, specifically, medullary thyroid cancer or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
The chronic nature of GLP-1 therapy requires sustainable financial planning
Objective testing such as gastric ultrasound can aid in selected cases but does not always exist or is not always accessible
N Engl J Med (2020) 383(12):111728
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