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the disulfide bond is sensitive to strongly reducing conditions

Zhang J, Zhou M, Zhou H, Zhao D, Gotor C, Romero LC, Xie Y (2021) Hydrogen sulfide, a signaling molecule in plant stress responses

For example, the body produces methylmalonic acid (MMA) in the blood when it's either not getting enough B12 or not using B12 properly

& Ahn, J.-M

The design minimized off-target amplification and ensured the inclusion of splice site mutations, as well as intronic regions known to harbor pathogenic and likely pathogenic variants reported in the ClinVar database (Fig