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doi: 10.1016/S0002-9440(10)65616-7 380 WendelnA
Research has demonstrated that GLP-1RAs significantly inhibit the expression of MMP-2 and MMP-9 in the human ovarian cancer cell line SKOV-3 within a TNF--induced inflammatory microenvironment, while simultaneously upregulating the levels of their inhibitors, tissue inhibitors-1 (TIMP-1) and tissue inhibitors-2 (TIMP-2) [78, 87]
What We DONT Know Yet Heres what we DONT have: We have no controlled trials of women deliberately taking GLP-1s during pregnancy (and well never have theseit would be unethical)
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Retatrutide further reduced plasma alanine aminotransferase and liver triglycerides, suggesting improvements in liver health [42]
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