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In the SURPASS-2 study, the three doses of tirzepatide (5, 10, and 15 mg once weekly) were tested with the GLP-1RA semaglutide (1 mg once weekly) as a comparator in patients not optimally controlled on monotherapy with metformin (71)
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[9] When that happens, GLP-1 signaling drops, insulin resistance increases, and metabolic dysfunction sets in
10.3389/fendo.2022.960279 55 KritschK
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