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Because the peptide is not FDA-approved, it exists in a regulatory gray area
Subcutaneous or intramuscular delivery is the only at-home route that produces the systemic NAD+ levels associated with published outcomes
A common dose is 1,000 mcg for those with deficiency
If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy
Dig Dis Sci 1987;32(12 Suppl):100S--7S
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