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Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]
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Hence, abnormal amino acid metabolism has diverse and important roles in various cancers, and the potential impact of metabolic control and regulation in the tumor microenvironment is becoming increasingly important
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At the signaling level, CPT enhanced autophagy by downregulating mTOR phosphorylation and p62 expression level and upregulating AMPK phosphorylation at T172 and LC3-II activation in the MPP + -treated cells (Fig
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