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PPARs as master regulators of carnitine homeostasis Genes regulated by peroxisome proliferator-activated receptor (PPAR) are involved in many biological processes such as fatty acid catabolism, ketogenesis and gluconeogenesis, and also play a key role in the regulation of carnitine homeostasis [189]

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Gene-modified MSC integrate in tumor stroma after systemic injection and inhibit tumor growth by paracrine effects of IFNb

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However, large-scale human clinical trials remain limited