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Christofk, H
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NRF2 reprograms cellular metabolism to funnel metabolic intermediates into antioxidant pathways While NRF2 regulates the expression of antioxidant and NADPH-generating enzymes, metabolic intermediates are required to support these pathways
Laboratory studies have investigated MOTS-c for roles in cellular metabolism, AMPK signalling, and metabolic stress responses
Research has focused on its facilitation of synapse formation via HGF/Met receptor signalling, with investigations suggesting neurotrophic potency orders of magnitude greater than BDNF in dendritic branching assays
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