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In 2009, EMA approved liraglutide for treatment of type 2 diabetes (T2D), followed by the approval of semaglutide for T2D treatment in 2018
These drugs havent been adequately studied in pregnant humans, but animal studies show potential risks, including: Embryo loss Fetal growth restriction Skeletal abnormalities Guidance for pregnancy planning: Stop Wegovy/Ozempic : At least 2 months before trying to conceive
How things go bad As we get older, our brain chemistry and energy metabolism changes.[vii] Nerve growth factor in the brain declines Acetyl-L-Carnitine levels decline Acetylcholine levels decline Mitochondria loses efficiency All of these age-related changes are contributing factors to cognitive impairment and the neurodegenerative diseases of aging, including Alzheimers and dementia
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These mechanisms improve glycemia and consistently produce clinically meaningful weight loss (Nauck & Meier, 2020)
The significant increase in platelet levels from day 1 to 7 in the Cohort 2 LCLT group suggests that LCLT may have an antithrombotic effect, which could be beneficial for COVID-19 patients with a high rate of thrombosis-induced complications
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