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In contrast, the concordance of benchmarking results for all outcomes, including mortality, in the SURPASS-CVOT emulation study comparing tirzepatide to dulaglutide provided support for the validity of evaluating these outcomes in expanded study populations
This is a dosing consideration that the calculator cannot address, because it involves pharmacokinetic interactions beyond simple concentration math
Although these data were subjected to match between runs processing and globally normalized, they were also subjected to three additional filtration steps prior to processing
The full Phase 3 programme, including TRIUMPH-3 and TRIUMPH-Outcomes, remains ongoing through 20272028
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