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This physiological effect, while not necessarily harmful, may contribute to the sensation of heart palpitations reported by some patients

Using fake/underdosed peptides This is the most common reason for "AOD 9604 doesn't work" complaints

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In the context of the thyroid, theres one obstacle with synthesizing glutathione peroxidase in sufficient quantities: selenium insufficiency

Thyroid peroxidase antibodies (anti-TPO) or thyroglobulin antibodies (anti-Tg) support the autoimmune aetiology but are not required for diagnosis, as hypothyroidism is diagnosed biochemically