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MHRA enforcement (20232025) against unlicensed weight-loss injections
While most patients taking a GLP-1 (79%) said they received the prescription from their primary care or other physician, nearly 1 in 5 reported getting the prescription from another source: an online provider or website (11%), a medical spa or aesthetic medical center (10%), or somewhere else (2%)
27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication
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Cultures were then normalized by OD 600 and pelleted by centrifugation (18,000 x g , 10 min, room temperature)
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