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In preclinical and early human studies, it did not produce meaningful increases in ACTH, cortisol, or prolactin, which distinguishes it from older secretagogues such as GHRP-2 and GHRP-6

Indeed, the consequences of naturally occurring mutations in GLP1R gene on receptor function and metabolic traits related to T2D and obesity, as well as the responsiveness to current GLP1R-based treatments had not been clearly established

When prescribing, the initiation phase includes more frequent visits for dose titration, side-effect monitoring and behavioral counseling

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Behavioral strategies proven effective for weight maintenance include consistent self-monitoring of weight (at least weekly), food logging, regular meal patterns, and cognitive behavioral techniques to address emotional eating and environmental triggers