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Typically, intramuscular treatment for dietary vitamin B12 deficiency begins with a loading dose followed by maintenance therapy, contrasting with the steady daily doses used in oral treatment due to limited passive absorption
However, their clinical translation is often impeded by inherent challenges such as poor bioavailability, limited aqueous solubility, and rapid systemic clearance, which collectively hinder their effective delivery to targeted ocular tissues [347]
Liang X, Wang Y, Li S, Fan J, Zhou F, Li X, et al
As an analogue of amylin, it is designed to be more stable and long-acting, overcoming some of the limitations of the natural peptide ( 6, 7 )
Its not uncommon to begin treatment at age 50
