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The most significant factor remains suboptimal glycaemic controlpatients with HbA1c levels above target are at substantially higher risk
J Clin Endocrinol Metab (2021) 106(1):e11e9
GLP-1 receptors are expressed on up to 70% cerebral arterioles [18] and endothelial cells, and experimental models demonstrate that GLP-1 signaling promotes arteriolar vasodilation, improved endothelial nitric oxide signaling, and angiogenic pathways such as VEGF upregulation, all of which enhance nutrient and oxygen delivery to metabolically active brain regions [13,14]
Early weight loss of 1-2kg was commonly reported
In this current network meta-analysis, we evaluated 23 CVOTs, including the most recently published trials AMPLITUDE-O and EMPEROR-P
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