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Conversely, a deficiency of brain insulin, as observed in transgenic mice, was associated with an increase in tau hyperphosphorylation, likely due to increased GSK3 activity [134]

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Document : Keep detailed records of any adverse events and the actions taken

further received funding from the Alexander von Humboldt Foundation, the Helmholtz Alliance ICEMED and the Helmholtz Initiative on Personalized Medicine iMed by Helmholtz Association, the Helmholtz cross-programme topic Metabolic Dysfunction and the European Research Council (ERC) AdG HypoFlam no

The study using UK CPRD data, which included a small population and thus had a limited outcome sample size, may impact the statistical power to evaluate the risk