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These studies revealed that tirzepatide is an imbalanced and biased dual GIP-R/GLP-1R co-agonist, which stimulates GIP receptors in a manner analogous to its parent peptide but favors cAMP generation over -arrestin recruitment at the GLP-1R

doi: 10.1038/leu.2015.139 190 ZhuBZhangHYuL

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