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"Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials." Diabetes, Obesity and Metabolism, 2026;28(1):83-93
Dose-dependent side effects While retatrutide has generally been well-tolerated, the clinical trials have also revealed a dose-dependent pattern in the occurrence of adverse events, particularly gastrointestinal (GI) side effects
Peptide therapy is a fantastic option for many, but it isnt the right fit for everyone
None of that is a moral failure
The key question will be durability: long-term tolerability, adherence, safety, cost, and whether these outcomes can be maintained outside highly selected trial populations
