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Mechanistic work in receptor-knockout mice shows the body-weight effect is preserved when GLP-1R is knocked out but blunted when GIPR is knocked out, indicating GIPR engagement contributes meaningfully to the anorectic phenotype

Others affect growth hormone release, fat metabolism, tissue recovery, or body composition

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Bone microarchitecture refers to the structure of cortical and trabecular bone, while bone turnover reflects how actively bone is being broken down and rebuilt