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Tumor suppression in humans relies on the immune system, but metastatic tumor cells can evade immune detection by using checkpoints like CTLA-4 and PD-1/PD-L1, thereby inhibiting immune responses and weakening anticancer immunity.This version simplifies and streamlines the information for better readability and clarity (Qin et al., 2019)

When tyrosinase is less abundant, the production of melanin is impeded, resulting in less skin pigmentation

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