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However, these are only surrogate outcomes the trial did not establish a clear reduction in major adverse cardiovascular events

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This naturally impacts low earners disproportionally, thus reducing their interest to participate in a clinical trial or increasing their trial drop-out rates, both adversely impacting patient diversity in iCTs

Seek urgent medical attention (call 999 or go to A&E) if you experience: Chest pain or tightness, particularly if radiating to the arm, jaw, or back Sudden shortness of breath at rest or with minimal exertion Palpitations accompanied by dizziness, fainting, or loss of consciousness Rapid or irregular heartbeat that does not resolve within a few minutes Sudden swelling of the legs or ankles combined with breathlessness (possible signs of heart failure) If you need urgent medical advice and it is not life-threatening, call NHS 111 or use 111 online

The concern about blood clots may stem from confusion with other weight loss interventions or from the fact that obesity itself is a significant risk factor for venous thromboembolism