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P & T 40:504532 Hwang O (2013) Role of oxidative stress in Parkinson's disease

Inefficient metabolism has been shown to lead to the accumulation of metabolic intermediates that can interfere with mitochondrial function and impair the ability to produce ATP

Treatments counteracting oxidative stress, such as the antioxidant, N-acetylcysteine (NAC), have proven effective in preventing the emergence of behavioural and cognitive disruptions in various models of neurodevelopmental disorders [10, 41,42,43]