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Zemba Cilic A, Zemba M, Cilic M, Strbe S, Ilic S, Vukojevic J, et al
La molcula no presenta homologa estructural con factores de crecimiento clsicos (VEGF, FGF, IGF-1), pero modula la expresin y actividad de mltiples sistemas trficos endgenos , posicionndola como agente pleiotrpico de proteccin y regeneracin tisular en investigacin experimental
In the Phase 2 obesity trial, the 12 mg weekly dose produced a mean weight reduction of about 24.2% at 48 weeks ( Jastreboff et al., NEJM 2023 ) the largest figure reported for any single agent in the incretin class at the time
At the same time, the delivery is moving from weekly injections to daily pills, with better tolerability, reduced cost, and demonstrated cardiovascular benefit on top of weight loss
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