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Oxidative Stress, SOD Enzymes and the Methylation Connection

Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1

If not monitored, these effects can lead to volume depletion and dehydration known risk factors for kidney injury and falls

Elegant studies of this type have been done for example by Leshan and colleagues to show that only a subpopulation of VTA dopamine neurons projecting specifically to the amygdala but not the NAc is activated by leptin (Leshan et al., 2010)

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