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DOI: 10.1161/JAHA.125.046302.

Side Effects Comparison Both medications share similar side effect profiles, mainly affecting your digestive system: Nausea (the most common) Vomiting Diarrhea Constipation Stomach pain According to meta-analysis data, adverse events occurred more frequently with retatrutide (risk ratio: 4.10) compared to tirzepatide (risk ratio: 2.78)

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These are usually mild to moderate, occur mainly during dose titration, and typically diminish as the body adjusts to the medication

HOW TO MINIMIZE UNWANTED SIDE EFFECTS Side effects can make or break your experience with the medication