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NDA: New Drug Application An NDA is made by the sponsor of the new drug who obtains and provides enough evidence of the drug's safety and effectiveness to meet the FDA's requirements for marketing approval

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The data is now worthless because you've introduced an uncontrolled variable

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In vitro anti-oxidation, anti-inflammation, anti-bacteria, and cell homing Inflammation and oxidative stress are two main pathological signs of progression in OA 39